For each pedigree below 1 determine the mode of inheritance

For each pedigree below: 1) determine the mode of inheritance; and 2) label any individuals that are known to be heterozygous or hemizygous dominant. For Pedigree (a), what is the probability that if II 3 has another child with his wife that the child will be affected? Show your work.

Solution

A PEDGIREE

RECESSIVE MODE OF INHERITANCE

I generation

1

Heterozygote –normal-genotype-------Aa

2

Homozygote –affected genotype-------aa

2 generation

1

Homozygote –affected genotype-------aa

2

Homozygote –affected genotype-------aa

3

Heterozygote –normal-genotype-------Aa

4

Heterozygote –normal-genotype-------Aa

5

Homozygote –affected -genotype-------aa

6

Heterozygote –normal-genotype-------Aa

3 generation

1

Heterozygote –normal-genotype-------Aa

2

Heterozygote –normal-genotype-------Aa

3

Homozygote –affected -genotype-------aa

4

–normal-genotype-------Aa OR AA

5

–normal-genotype-------Aa OR AA

6

Heterozygote –normal-genotype-------Aa

PEDIGREE -B

X- LINKED RECSSIVE MODE OF INHERITANCE

I GNERATION

1

NORMAL CARRIER FOR ABONRMAL RECESSIVE ALLELE

X X^c

2

XY-------NORMAL MALE

II GENERATION

1

X^c Y-------AFFECTED MALE

2

NORMAL CARRIER FOR ABONRMAL RECESSIVE ALLELE

X X^c

IIII

2

NORMAL CARRIER FOR ABONRMAL RECESSIVE ALLELE

X X^c

3

XY-------NORMAL MALE

4

X^c Y-------AFFECTED MALE

5

NORMAL      WITH GENOTYPE

X X^c   OR XX

IV

1-3

NORMAL

4

X^c Y-------AFFECTED MALE

5

NORMAL      WITH GENOTYPE

X X^c   OR XX

A PEDGIREE	RECESSIVE MODE OF INHERITANCE
I generation
1	Heterozygote –normal-genotype-------Aa
2	Homozygote –affected genotype-------aa
2 generation
1	Homozygote –affected genotype-------aa
2	Homozygote –affected genotype-------aa
3	Heterozygote –normal-genotype-------Aa
4	Heterozygote –normal-genotype-------Aa
5	Homozygote –affected -genotype-------aa
6	Heterozygote –normal-genotype-------Aa