The binding energy of two enzymes E1 and E2 are 8 kJ mol1 an

The binding energy of two enzymes, E1 and E2 are 8 kJ mol^-1 and 12 kJ mol^-1 respectively. Based on this information, can you predict which enzyme will have a higher V_max? If yes, predict which enzyme has a higher V_max, and explain your answer. If no, explain why not.

Solution

No we can not predict the Vmax by simply seeing binding energy of the reaction.

Enzymes lower activation energy G‡ not the free energy G of a reaction.

A large -G value reflect a favouable reaction equillibrium but it does not mean that the reaction will proceed at a rapid rate.