Give background information concerning EMT and include what

Give background information concerning EMT and include what is known about EMT in normal development as well as in neoplasms. What are strategies that could be used to overcome drug resistance in cancer cells by targeting EMT (minimum four paragraphs).

Solution

Answer:

Cancer stem cell (CSC) hypothesis: This hypothesis elucidating that the CSC are the subpopulation and able to exert higher resistance associated with explicit capability to self-renew finally to differentiate into different offspring of cancer cells to generate a tumor. This hypothesis is based on the cellular mechanisms exclusively developed inside the CSC to exert resistance such pathways are mainly through Wnt signaling, Notch signaling. There are other targets to regulate proliferation and differentiation through ABC transporter system and receptor tyrosine kinases. These targets are the future stem cells anti-cancer therapies in regulating the proliferation & differentiation of cancer cells as CSCs have a potential relationship with epithelial-mesenchymal transition (EMT).

Metastasis has many steps. The main cancer cell morphological features that support invasion, intravasation, and extravasation are epithelial-mesenchymal transition via cell -adhesion molecules. Invasion is mainly due to presence of cell adhesion molecules such as integrins on the cancer cells finally promote the movement of cancer cells to another region. This process is going to connect adjacent cells to tumor cells finally undergo epithelial-mesenchymal transition (EMT) result in formation of \"continuously dividing neoplasms\" with higher drug resistence to cure compared to normal cells

Strategies that could be used to overcome drug resistance in cancer cells by targeting EMT:

\"A combination therapy of neutraceuticals & chemotherapeutic agents\" are most promising strategies to overcome drug resistance in cancer cells by targeting EMTs, cancer stem cells (CSC) &

Modulation of microRNAs do promote effective strategy to overcome drug resistance in cancer cells

Oligonucletodie deliver: Another strategy could be used to overcome drug resistance in cancer cells by targeting EMT. In this method, synthesized microRNAs are going to make in the form of \"nanoparticle or microsomal\" formulation finally used to target microRNAs in cancer cells result in \"complete destruction of pre-mRNA\" finally there will no translation mechanism to synthesize \"cell survival proteins\" to proliferate