Place the following events of activation of intracellular nu

Place the following events of activation of intracellular (nuclear) receptors in the correct chronological order. (1=earliest event, 6=latest event)

The hormone-receptor complex forms a dimer in the nucleus of the target cell

After being released from its carrier protein, a lipid-soluble hormone readily crosses the cell membrane of a target cell

Binding of the hormone-receptor complex to the HRE can either activate or deactivate a gene resulting in either synthesis or end of synthesis of a protein

The hormone-receptor complex binds to a certain region of the DNA called the hormone response element (HRE)

Binding of the hormone to its receptor causes the release of heat shock proteins and exposure of the zinc fingers

The lipid-soluble hormone binds to a receptor locaed in the cytosol or the nucleus of the target cell

Solution

1. After being released from its carrier protein, a lipid-soluble hormone readily crosses the cell membrane of a target cell

2. The lipid-soluble hormone binds to a receptor located in the cytosol or the nucleus of the target cell

3. Binding of the hormone to its receptor causes the release of heat shock proteins and exposure of the zinc fingers

4. The hormone-receptor complex forms a dimer in the nucleus of the target cell

5. The hormone-receptor complex binds to a certain region of the DNA called the hormone response element (HRE)

6. Binding of the hormone-receptor complex to the HRE can either activate or deactivate a gene resulting in either synthesis or end of synthesis of a protein