How can a topologically associating domain TAD mutation effe

How can a topologically associating domain (TAD) mutation effect more that one gene? Explain why a TAD mutation shouldn\'t have any effect on the normal shape of a protein? And what seems to be one of the normal functions of a TAD.?

Solution

Topological associated domain are genome region whose DNA sequence prefrentially contact each other.

TAD is a fundamental structural unit that regulates elements to their cognate promoters.Function: TAD are critical for accurate gene expression Any aleration can lead to disease