Can you explain how to do this question and please show your

Can you explain how to do this question and please show your work?

Rint Rint Rint Rmem Rmem Rmem Vap Rext Rext Rext Stage 1 Figure 3. A three stage simplified resistive core conductor circuit model for an excitable cell where Rint is the resistance due to intracellular fluid, Rext is the resistance due to extracellular fluid, Rmem is the resistance of cell membrane, and Vap is the voltage waveform of the action potential. Post-LQ 8: Post Lab Design Activity: Skeletal muscle is an excitable tissue that contracts when stimulated. In general, it is stimulated by motor neurons. These motor neurons are specialized nerve cells whose cell bodies are located in the brainstem or spinal cord and whose axons innervate the muscle fibers. The motor neurons stimulate the muscle fiber at the myoneural junction. For our purposes, assume the myoneural junction is located at the R of the last stage of a 12 cm long mem nerve fiber similar to Figure 3. The voltage at the myoneural junction required to initiate a muscle contraction is 1 mV. Determine the appropriate magnitude value of the initiating motor neuron action potential (Vap) that will induce this muscle contraction. Comment on the magnitude derived and propose a mechanism to bring this voltage into a more physiologic realm Hint: Try to derive a function capable of analytically determining the voltage at n-stages. Use 12 stages to solve problem.

Solution

R1 = Rext + Rint + Rmem

R2 = R1//Rmem

R3 = R2 + Rext + Rint

R4 = R3//Rmem

R5 = R4 + Rext + Rint

Vap = I * R5