Nitroglycerin is a vasodilator used to treat angina attacks

Nitroglycerin is a vasodilator used to treat angina attacks. This drug is livid soluble, so it is easily absorbed through mucous layers. It is rapidly and nearly completely metabolized into an inactive for in the liver (>99%). If 0.5mg this drug was given orally, how much would be found in the systemic system? If 0.5mg taken sublingually or via a spray in the mouth, how much would be found systemically immediately after dosage? 0.5 The entire volume of blood circulates one trip through a body in about 1 min. Given this, how much of the nitroglycerin administered via the mucous would still be in the body after 5 minutes?

Solution

The biological half life of Nitroglycerin is 3 minutes.So,the plasma concentrations of nitroglycerin will decrease to half by 3 minutes and after 5 minutes to 0.So, the answer is 0.