Receptor tyrosine kinases you may want to review this family

Receptor tyrosine kinases (you may want to review this family of receptors) have a ligan-binding domain on the outside of a cell and a kinase domain on the inside of the cell. Select all tru statements:

1.Antibodies can be used to block the ligand-binding domain

2.Antibodies can be used to block the activity of the kinase domain

3.ATP and its analogs bind the kinase domain

4.The signal (ligand binding) is often transduced through dimerization of the receptor

5.Upon ligand binding the receptors localize to the nucleus to change gene expression

6.Because they have extracellular domains, hydrophilic drugs can easily target these receptors

Solution

All statement are correct regarding receptor kinases

Both statement one and two Antibodies can be used to block the ligand-binding domain and Antibodies can be used to block the activity of the kinase domain are true.

Ligand binding inhibitor is antibody is cetuximab whereas the geftimab prevents the autophosphorylation.

ATP helping in phosphorylation reaction. kinase is a type of enzyme that transfers phosphate groups from high-energy donor molecules, such as ATP.

other two option are important part of the signaling cascade of tyrosine kinase.