Describe the process of Ig development on the B cell as it g

Describe the process of Ig development on the B cell as it goes from a pre-B to a mature/naïve cell, to a functional effector/memory cell.

Solution

B-cells derived and mature in the Bone marrow produce Immunoglobins or Antibodies and excecute Humoral Mediate Immunity.

B cell development occurs through several stages, each stage representing a change in the genome content at the antibody loci. An antibody is composed of two identical light (L) and two identical heavy (H) chains, and the genes specifying them are found in the \'V\' (Variable) region and the \'C\' (Constant) region. In the heavy-chain \'V\' region there are three segments; V, D, and J, that recombine randomly, in a process called VDJ recombination, to produce a unique variable domain in the immunoglobulin of each individual B cell. Similar rearrangements occur for light-chain \'V\' region except there are only two segments involved; V and J. When the B cell fails in any step of the maturation process, it will die by a mechanism called apoptosis, or specifically, clonal deletion. B cells are continuously produced in the bone marrow. When the B cell receptor, on the surface of the cell matches the detected antigens present in the body, the B cell proliferates and secretes a free form of those receptors (antibodies) with identical binding sites as the ones on the original cell surface. After activation, the cell proliferates and B memory cells would form to recognize the same antigen. This information would then be used as a part of the adaptive immune system for a more efficient and more powerful immune response for future encounters with that antigen. Like their fellow lymphocytes, the T cells, immature B cells are tested for auto-reactivity by the immune system before leaving the bone marrow. In the bone marrow (the central lymphoid organ), central tolerance is produced. The immature B cells whose B-cell receptors (BCRs) bind too strongly to self antigens will not be allowed to mature.