Why might muscarinic cholinergic receptors be targeted in th

•Why might muscarinic cholinergic receptors be targeted in the management of asthma?

Solution

The lung’s primary role is gas exchange, but it also serves as both a barrier and defense against pathogens and environmental contaminants. Acetylcholine produced and released by both neuronal and nonneuronal sources acts through muscarinic receptors to regulate these important physiological functions. Acetylcholine contracts airway smooth muscle to control tone and regulate patency of the conducting airways. In blood vessels, acetylcholine causes smooth muscle relaxation and vasodilation. At mucosal glands and epithelial cells, acetylcholine regulates mucus secretion and, via ciliary beat frequency, mucus clearance. Acetylcholine also modulates inflammation.