5 Shift to the left in reference to platelet formation sugge

5

Shift to the left in reference to platelet formation suggest the occurrence of which of the following?

A megakaryocytes with lower ploidy

B megakaryocytes with higher ploidy

C Larger sized megakaryocytes

D ( B,C,D are correct)

6

Which of the following tests would be used for assessment of primary hemostasis?

A     APTT

B closure time

C   all of the above

D B and C only

7 A key function of T helper lymphocytes is to:

A          Engulf pathogens by the process of phagocytosis

B          Produce antibodies

C          Produce cytokines that modulate the activity of other leukocytes

D         Induce virus infected cells to undergo apoptosis

8. An endurance runner has just completed a 10K race. Blood is drawn for a research study on hemoglobin oxygen dissociation. What would you expect the findings to show regarding the oxygen dissociation curve?

A          No changes should occur in a well-conditioned athlete

B          There would be an increased oxygen affinity

C          The curve will be shifted to the left

D         The curve will be shifted to the right

9. Which of the following is false regarding primary hemostasis

A          At high shear rates, VWF mediated platelet adhesion to collagen

B          Platelets undergo dramatic shape change following adhesion to subendotheiai collagen.

C          The primary plug includes platelet aggregation stabilized covalent linkages in fibrin

D         Activated platelets secrete platelet agonists

10. Genetic analysis of hematopoietic neoplasms may involve

A          Karyotype analysis

B          FISH(fluorescence in situ hybridization)

C          PCR

D         DNA sequencing

E          All of the above

11. Which of the following conditions are not applicable to DIC

A          Consumption coagulopathy

B         Altered hemostatic balance

C          Vitamin K deficiency

D         Whole body inflammatory response

12. Which of the following statements about hematopoietic stem cells is false

A     HSCs undergo asymmetric cell division, in which one daughter cell retains self-renewal properties and the other daughter cell undergoes differentiation

B     HSCs constitute about 20% of the total bone marrow nucleated cells

C      HSCs spend most time in a quiescent non-dividing state

D    HSCs are not morphological distinguishable from small lymphocytes

13 when of the following would not provide a source of hematopoietic stem cells for bone marrow transportation

A   umbilical cord blood

B    bone marrow

C blood from the spleen red pulp regions

Peripheral blood following G-GSF and GM -CSF treatment

Solution

6.Which of the following tests would be used for assessment of primary hemostasis?

A         aPTT:

            Activated Partial Thromboplastin Time (aPTT): This test is used to measure time to generate fibrin during intrinsic pathway.

7.         A key function of T helper lymphocytes is to

c.         Produce cytokines that modulate the activity of other leukocytes

            particularly in the adaptive immune system. They help the activity of other immune cells by releasing T cell cytokines. These cells help suppress or regulate immune responses.

10.       Genetic analysis of hematopoietic neoplasms may involve

E.         All of the above

Hematopoietic neoplasms are clonal disorders of hematopoietic cells, which constitute red cells, white cells, and platelets. They typically manifest as leukemias, lymphomas, and plasma cell disorders. Leukemias predominantly involve peripheral blood and bone marrow, while lymphomas involve tissue-based sites such as lymph nodes, stomach, or skin.

Analysis of these hemotopoietc neoplasms involves all of these test

Karyotype analysis

FISH(fluorescence in situ hybridization)

PCR

DNA sequencing