Prince Charles is the designated next king of England His ma

Prince Charles is the designated next king of England. His marriage to Princess Diana produced two sons before it ended in an acrimonious divorce. If you learned that one of the two sons was a hemophiliac, what are the possible explanations for this disease?

Solution

Answer:

This is a X-Linked Recessive Inheritance: two copies of a disease allele on the X chromosome are required for an individual with two X chromosomes (a female) to be affected with an X-linked recessive disease.

For a carrier female, with each pregnancy there is a one in two (50%) chance her sons will inherit the disease allele.