how does changes in the resting membrane potential of neuron

how does changes in the resting membrane potential of neurons lead to seizures and epilepsy?

Solution

Epilepsy and seizures are common neurological disease associated with EEG changes, the waves having distinctive high amplitudes (upto 1000 mV) and individual spikes or combinations of spikes and waves. This disease is also associated with stereotyped changes in behaviour that vary according to the part of the brain affected and can include a temporary loss of consciousness. While we often think of neural activity in terms of action potentials, they ususally contribute little to the EEG. Rather, EEG patterns are largely due to graded potentials, in this case summed postsynaptic potentials in the many hundreds of thousands of brain neurons that underlie the recording electrode.