Entire genes may be deleted inverted replicated or even tran

Entire genes may be deleted, inverted, replicated, or even translocated to another chromosome. Explain how each one could potentially result in cancer.

Solution

Deletions , inversions, duplications and translocations are different type of chromosomal abberrations resulting in either removal of a gene ,set of genes as in deletions or they may change the order of gene sequence as in case of inversions or there may be replacement of deleted segment from chromosome to another when it is said to be translocation. whatever may be the nature of the abberration the effect of the abberration has a profound effect on the system depending on the nature of the gene involved and hence all these abberration have a role to play in promoting cancer.

Deletion of a tumor suppressor gene may result in uncontrolled growth of cell and hence cause cancer.

If a functional gene like a tumor suppressor gene is located in the inverted locus it may result it rendering the gene non functional and hence the cells proliferate in an uncontrolled manner and hence cause cancer.

Similarly the replication of an oncogene (gene responsible for cancer) results in over production of the cancerous cells.

In case of translocations if translocations involve at the sites of tumor supressor genes it may fail to initiate the transcription process as it lacks transcription factors or the promoter site neccessry for transcription.