Mice that make uncoupler proteins in their hypothalmus are d

Mice that make uncoupler proteins in their hypothalmus are described in the Saper paper. How is this accomplished?

The construct is expressed in the hypothalamus, and the uncoupler activity increases the local temperature

The construct is expressed in hypothalamus where it interferes with uncoupled activity so that body is cooled.It showed that if body temperature is low lifespan may increase.