Dentinogenesis imperfecta is a tooth disorder involving the

Dentinogenesis imperfecta is a tooth disorder involving the production of dentin sialophosphoprotein, a bone-like component of the protective middle layer of teeth. The trait is inherited as an autosomal dominant allele located on chromosome 4 in humans and occurs in about 1 in 6000 to 8000 people. Assume that a man with dentinogenesis imperfecta, whose father had the disease but whose mother had normal teeth, married a woman with normal teeth. They have six children.

Solution

A man who is affected with dentinogenesis imperfecta married a woman with normal teeth and they have six children. Out of six children only two girls will be affected with disorder and rest of four children are unaffected including three boys and one girl.