Assume you made a DNA analogue called XNA containing the WXY

Assume you made a DNA analogue (called XNA) containing the WXY and Z bases on a phosphoribose backbone, and then hybridized it with its complementary strand. Assuming random sequences of DNA and XNA of the same lengths, which would you expect to have the higher melting temperature and why?

Solution

XNA or Xeno Nucleic acid is a synthetic NA. They are usually synthesised for use as probes or study them for their hybridization and affinity. The XNA have high melting temperature thans the natural DNA assuming their lengths and base sequences are random. The only trick here is the WXYZ bases attached to the phosphoribose backbone which is nothing but the ATGC bases with different sugar moieties which gives them the strength and the binding efficiency.