What is the frequency of unilateral and bilateral retinoblas

What is the frequency of unilateral and bilateral retinoblastoma? How does this relate to whether the mutation is germline or somatic?

Solution

Retinoblastoma is very rare disease. It is most common eye tumor in children . Frequency of retinoblastoma occurrence has increased in past few decades. It is now 1 out of every 1500 children.

Approximately 60% cases are unilateral and 40 % are bilateral.

Unilateral occur one eye while bilateral occur in two eye. Bilateral is genetically i.e hereditary while unilateral is nonhereditary