CASE 16 Allo steric Regulation of ATCase 5 of 6 2 Gerhart an

CASE 16 Allo steric Regulation of ATCase 5 of 6 2, Gerhart and Pardee developed a model for the regulation of the activity ofthe ATCase enzyme by CTP and ATP, using the pathway given in Figure 16.1. Describe that model, using information presented here as well as what you have learned about allosteric enzymes. Be sure to include a sentence explaining the physiological significance of your model

Solution

It is a allosteric regulation model. ATCase is an allosteric enzyme which means this enzyme is inhibited by the endproduct of this pathway that is CTP which is a pyrimidine. ATCase condenses L-aspertate and carbomoyl phosphate into N-carbamyl-L-aspertate.

ATP is an end product of purine pathway, which increases the catalytic activity of ATCase.