Suppose you obtain a novel dietary supplement in a liquor st

Suppose you obtain a novel dietary supplement in a liquor store. According to the label, this supplement increases the mobility (within the membrane) of proteins with a single transmembrane segment, but not proteins with two transmembrane segments. Describe an experiment to test this using a cell-cell fusion approach.

Solution

Proteins enter and move within the membrane through lipids. Today\'s food industries use AGEs(Advanced Glycation End) products in their dietary supplements in order to increase the mobility of proteins within the membranes that can prevent ageing, neurodegeneration, cardiovascular disease and arteriosclerosis.

The presence of AGEs in a dietary substance can be tested by its reaction with glucose in combination with amino acid glycine.The end product that we get is brown in colour which was first discovered by Maillard in 1921 and is known as the browning reaction.

Cell wall sorting is one such experiment using a cell-cell fusion to test the mobility of protein in a single transmembrane segment.If the cell wall has a non-covalent attachment of protein in order to penetrate the transmembrane of the cell via specialised binding domain of the cell membrane.