The neurologist continued Do you remember when the nurse Inj

The neurologist continued: \"Do you remember when the nurse Injected that solution Into your arm and you said that suddenly you felt much stronger?\" \"Yes, I felt so much better, but only for a short time, \" replied Annie. \"That was the edrophonium test; we injected edrophonium chloride into your vein. It is a reversible acetylcholinesterase inhibitor. We also got lab results back showing high concentrations of antibodies in your blood. Antibodies are part of your body\'s immune response; they are made when certain white blood cells encounter antigens, or things foreign to your body. Normally, they\'re beneficial, but sometimes things can go haywire, and they attack the body\'s own proteins. I\'m afraid these results are confirming my diagnosis. What is acetylcholinesterase? Why would inhibiting it help Annie? What might the antibodies be attacking? What proteins are necessary for ACh signal to be relayed? What do you predict the doctor\'s diagnosis will be?

Solution

2g. Acetylcholinesterase,also known as AChE is the primary cholinesterase (esterase that lyses choline-based esters which serve as neurotransmitters) in the body.The enzyme AChE terminates synaptic transmission at cholinergic synapses by hydrolizing the neurotransmitter acetylcholine.Acetylcholinesterase inhibitors uses to treat glaucoma,postural tachycardia syndrome,Alzheimer\'s disease,myasthenia gravis etc.The acetylcholinesterase inhibitors increase the amount of acetylcholine that help in muscle contraction.Reversible AChE inhibitors plays an important role in pharmological manipulation of enzyme activity.

2h. AChE antibodies hinder the action of acetylcholine.ACh-binding proteins are necessary for ACh signal.

2i. The doctor will diagnose the disease \'Myasthenia Gravis\'.Acetylcholinesterase inhibitors are considerd to be the basic treatment of myasthenia gravis (MG).Endophonium test is primarily use to diagnose myasthenia gravis.