Goldstein and brown were lucky If they had used the JD allel

Goldstein and brown were lucky. If they had used the JD allele to compare with wild type rather than an allele that results in complete loss of the LDLr protein, the graph of _____ would look much different.

Solution

Answer is LDL import.

NPVY domain recruits clathrin and other proteins responsible for the endocytosis of LDL, therefore this mutation inhibits LDL internalization. \"JD\" mutant results from a single point mutation in the NPVY domain