Pick only one of the following choices as the answer to the

Pick only one of the following choices as the answer to the question please.

Why do mice engineered to express the Orexin::UCP2 construct cool down at night? The construct is expressed in brown fat and increases uncoupler activity, which lowers body temperature. The construct is expressed in the hypothalamus, and the uncoupler activity increases the local temperature The construct is expressed in the quasimut lumbrucus, where it interferes with neuroantipathetic signaling The construct is expressed in brown fat and reduces uncoupler activity, which in turn reduces metabolic rate. The lowered metabolic rate leads to reduced body temperature. The construct is expressed in the hypothalamus, where it interferes with uncoupler activity so that the body is cooled.

Solution

The correct answer is:

The construct is expressed in the hypothalamus and the uncoupler activity increases the local temperature.