An individual with genes A H Se and lele has which of the fo

An individual with genes A, H, Se and lele has which of the following phenotypes?

AH, Le(a-b-)

ABH, Le(a+b-)

ABH, Le(a-b-)

AH, Le(a+b-)

The Rh phenotype results for a patient are: anti-C = 4+, anti-c = 3+, anti-D = NEG, anti-E = NEG, anti-e = 4+. The patients most probable genotype using the Wiener nomenclature is?

r\'r

R1r

r\"r

rr

With respect to the Lewis blood group system, which statement is false.

Lewis antibodies occur frequently in the sera of pregnant women.

Lewis blood group antigens are made by tissue cells, secreted into body fluids and plasma, and adsorbed onto the red cell membrane.

The Le gene codes for L-fucosyltransferase which adds L-fucose to the type 1 chain.

Lewis antigens are well developed at birth.

Lewis antibodies are generally IgM, and are therefore not a cause of HDN.

The major immunoglobulin class of anti-B in a group A individual is:

IgM.

None of the alternatives

IgA.

IgG.

Antibody screening cells may not detect antibodies against low frequency antigens. Which of the following is most likely to go undetected?

K

Kpa

M

k

e

Rh antigens are inherited as?

Codominant alleles.

X linked.

Sex-linked genes.

Autosomal recessive alleles.

Solution

An individual with genes A, H, Se and lele has which of the following phenotypes?

answer: AH, Le(a-b-) . if B antigen is not found.

if B antigen is present then ABH, Le(a-b-)

The Rh phenotype results for a patient are: anti-C = 4+, anti-c = 3+, anti-D = NEG, anti-E = NEG, anti-e = 4+. The patients most probable genotype using the Wiener nomenclature is?

answer is R1r

positive sign shows that antigens are present. so we can see here that D,d, C,c,e are present on RBC. D and C are homo and heterozygous whereas e is only homozygous.

combinations are DCe/dce, Dce/dCe, Dce/DCe. when they are converted into fischer race chart. among these phenotypes,R1r is the most probable one.

With respect to the Lewis blood group system, which statement is false.

answer: Lewis antigens are well developed at birth. they cannot be detected until 2 years of birth.

The major immunoglobulin class of anti-B in a group A individual is

answer: IgM. Major immunoglobulin class for anti-b in group A individual or anti-a in group B individual is IgM.

Antibody screening cells may not detect antibodies against low frequency antigens. Which of the following is most likely to go undetected?

answer: Kp-a, low frequency antigens are K,Kp-a, Le-a and Js-a

Rh antigens are inherited as?

answer: codominant alleles which are present on autosomes