What is the typical role of a sorting receptor A It binds to

What is the typical role of a sorting receptor?

A. It binds to the signal sequence of a protein and targets the protein for degradation.

B. It binds to the signal sequence of a protein and targets the protein t to a machinery that moves the protein into a new location

C. It cleaves off the signal sequence

D. It binds the signal sequence only in the presence of ATPD.

E. It recognizes a hydrophobic patch within the protein

Solution

The typical role of a sorting receptor is to recognize a hydrophobic patch within the protein .The process of protein sorting occurs cotraslationally in the case of secretory, membrane-bound, or Endoplasmic reticulam, golgi or endosomes resident proteins. It includes following path:

1). protein synthesis on free ribosomes (non membrane bound)

2). first the syntheis of signal sequence takes place in the amino terminal of the nascent polypeptide.

3). this sinal sequence and ribosome are bound to the large signal secognition particle(SRP)

4). The SRP will be recognized by the GTP bound SRP receptor connected with the sorting receptor.

5). The sorting receptor recognizes the hydrophobic patches with in the polypeptide and get bound to the protein via signal sequence.

6). signal sequence then cleved by the signal petidases.