Trypsin like other members of the serine protease family con

Trypsin, like other members of the serine protease family, contains in its active site three critical residues, referred to as the catalytic triad and shown in the figure at the right. In this drawing, the bonds between backbone atoms are shown in dark gray, and the side-chain bonds are light gray.Briefly but specifically, describe the role of each of these residues in the catalytic mechanism of a serine protease:

A) His 57

B) Ser 195

C) Asp 102

Solution

His 57, Ser 195 and Asp 102, three key amino acids each of them play an essential and specific role in the cleaving of the proteases.