Place the following events of activation of Gprotein coupled

Place the following events of activation of G-protein coupled receptors in the correct chronological order. (1=earliest event, 6=latest event)

The G-protein stimulated adenylate cyclase to produce large amounts of cyclic AMP (cAMP) from ATP

Protein kinase A phosphorylates a target protein with the cell

The second messenger cAMP activated protein kinase A

After phosphorylation, the activity of the target protein is altered

A water-soluble hormone binds to a G-protein coupled receptor on the membrane of a target cell

The G protein on the inside of the target cell becomes activated

Solution

1). A water-soluble hormone binds to a G-protein coupled receptor on the membrane of a target cell

2). The G protein on the inside of the target cell becomes activated

3). The G-protein stimulated adenylate cyclase to produce large amounts of cyclic AMP (cAMP) from ATP

4). The second messenger cAMP activated protein kinase A

5). Protein kinase A phosphorylates a target protein with the cell

6). After phosphorylation, the activity of the target protein is altered