Homework SourseWith respect to antibodies to the Kidd system which statemen
With respect to antibodies to the Kidd system, which statement is false?
Kidd antibodies have a frequent association with delayed haemolytic transfusion reactions.
The antibodies typically react poorly in vitro, but may result in severe cell destruction in vivo.
Both anti-Jka and anti-Jkb detect differences in antigen dosage, that is they may only react with screening or donor cells that have homozygous expression of the respective antigens.
Anti-Jka is usually found in conjunction with other antibodies, anti-Jkb is rarely found in conjunction with other antibodies.
anti-Jka and anti-Jkb do not bind complement.
Anti-i is sometimes found in association with?
Associated with infectious mononucleosis and a transient haemolytic anaemia.
Frequent cause of haemolytic disease of the new born.
Secondary cold agglutinin disease.
A warm autoantibody.
Rh antibodies react best at which temperature?
22 degrees C.
4 degrees C.
37 degrees C.
15 degrees C.
Because the D antigen appears to be a mosaic, then with respect to monoclonal anti-D reagents:
Are for use in high protein environments.
Anti-D reagents are a combination of different monoclonal anti-Ds to ensure reactivity with a wide spectrum of Rh positive cells.
Don\'t include dyes as these interfere with the agglutination strengths.
Solutions of antibodies that have the disulphide bonds broken.
| Kidd antibodies have a frequent association with delayed haemolytic transfusion reactions. | ||
| The antibodies typically react poorly in vitro, but may result in severe cell destruction in vivo. | ||
| Both anti-Jka and anti-Jkb detect differences in antigen dosage, that is they may only react with screening or donor cells that have homozygous expression of the respective antigens. | ||
| Anti-Jka is usually found in conjunction with other antibodies, anti-Jkb is rarely found in conjunction with other antibodies. | ||
| anti-Jka and anti-Jkb do not bind complement. |
Solution
With respect to antibodies to the Kidd system, which statement is false?
answer: Anti-Jka is usually found in conjunction with other antibodies, anti-Jkb is rarely found in conjunction with other antibodies.
they are rarely found
Anti-i is sometimes found in association with?
answer: Associated with Secondary cold agglutinin disease.
it is best detected at 4C but also detected at RT. it is associated with cold agglutinin syndrome followed by mononucleosis.
Rh antibodies react best at which temperature?
answer: 37C
Because the D antigen appears to be a mosaic, then with respect to monoclonal anti-D reagents:
answer: Anti-D reagents are a combination of different monoclonal anti-Ds to ensure reactivity with a wide spectrum of Rh positive cells.
D antigen is mosaic. it consists of distinct pieces of protein. (anti D alloantibody)
| With respect to antibodies to the Kidd system, which statement is false? answer: Anti-Jka is usually found in conjunction with other antibodies, anti-Jkb is rarely found in conjunction with other antibodies. they are rarely found |
