A Tell everything that cannot happen if p53 is missing from

(A) Tell everything that cannot happen if p53 is missing from a cell.

(B) Tell everything that will happen if p53 is missing from a cell.

(C) What makes second messengers different from other molecules involved in signal transduction?

Solution

A) if p53 is missing or mutated or dysfunctional cell cannot commit suicide (apoptosis).

B) if p53 is missing cells will continue to divide repeatedly. There is will beno regulation of cell divisions. In maximum cancerous patients, p53 is either missing or mutated.

C) second messengersare released by the cell in response to first messengers. Example cyclic AMP , Cyclic GMP etc.

First messengers are usually extracellular factors such aa hormones, neurotransmitters etc .which then cause cell to release second messengers which are small molecules that bind to protein kinases, open ion channels and thereby continue the signalling cascade.