Deponit is a nitroglycerine transdermal delivery system for

Deponit is a nitroglycerine transdermal delivery system for the prevention of angina pectoris. The in vivo release rate of the 16 cm: patch is 0.2 mgh The reported volume of distribution is 3 L kg 1 BW 1 and the observed clearance rate is 3 L kg BW^-1min^_1. What is the steady state nitroglycerine concentration (nanograms per millileter) in a 70 kg human? What is the elimination rate constant in 1 min^-1? What is the half-life of nitroglycerine in minutes?

Solution

solution:

Elimination rate constant (rate of elimination of drug from the body),

Ke = Clearance (CL)/ Volume of distribution (Vd) = 1 L/kg/min /  3 L/kg = 0.33/ min

ANSWER:0.33/MIN

Elimination half life (time required to reduce the plasma concentration of the drug to the half)

t1/2 = ln (2)/ Ke = 0.30/0.33 = 0.9 min.

ANSWER=0.9MIN