Determine if the dosage ordered is safe If the order is safe

Determine if the dosage ordered is safe. If the order is safe, then find the amount to administer. Assume the patient has impaired renal function.

The patient: 82-year-old female, 4 ft 10 in. tall, 102 lb, CLCR of 26 mL/min. Patient is within ideal weight range.

Ordered: Acyclovir sodium (Zovirax®) 450 mg IV q12h infused over 1 h

On hand: Zovirax® for injection, 50 mg/mL when reconstituted

According to the package insert, the recommended dose for this diagnosis for patients with normal renal function is 10 mg/kg q8h. The dose is adjusted as follows for patients with impaired renal function: for creatinine clearance over 50 mL/min, 100% of the recommended dose every 8 h; from 25 to 50 mL/min, 100% of the recommended dose every 12 h; from 10 to 25 mL/min, 100% of the recommended dose every 24 h; for 0 to 10 mL/min, 50% of the recommended dose every 24 h.

Is the dose safe or unsafe?

A=__mL

Solution

According to the package insert, the recommended dose for this diagnosis for patients with normal renal function is 10 mg/kg q8h. The dose is adjusted as follows for patients with impaired renal function: for creatinine clearance over 50 mL/min, 100% of the recommended dose every 8 h; from 25 to 50 mL/min, 100% of the recommended dose every 12 h; from 10 to 25 mL/min, 100% of the recommended dose every 24 h; for 0 to 10 mL/min, 50% of the recommended dose every 24 h.

Is the dose safe or unsafe?

ANSWER : SAFE DOSE

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ANSWER :

AMOUNT TO ADMINSTER = 9 mL

=(Ordered /On hand ) X10 mL =

=(450 / 500) *10 = 9 ml

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