Membrane tyrosine kinase receptors include among others the

Membrane tyrosine kinase receptors include, among others, the insulin and erythropoietin receptors. How does insulin receptor activation differ from that of erythropoietin receptor activation?

Solution

Insulin receptor activation :-The binding ligand to the insulin receptor at the cell surface triggers autophosphorylation at the tyrosine residue that triggers the uptake of glucose from the blood into the cell for glycolysis of conversuon into glycogen ghus bringing homeostasis.

Activation of erythropeitin receptor :-its type of cytokine receptor which upon binding by appropriate ligand undergoes conformational changes that cauae autophosphorylation of jak2 kinases that are already associated with the receptor.