Problem 48 Occasionally a mouse X chromosome is broken into

Problem 48) Occasionally, a mouse X chromosome is broken into two pieces and each piece becomes attached to a different autosomal chromosome. In this event, the genes on only one of the two pieces undergo X inactivation. What does this observation indicate about the mechanism of X-chromosome inactivation? (Ignore the levels of expression of autosomal genes that become attached to the X-chromosome pieces.)

One of the pieces of the X chromosome contains the SRY gene and the other one does not.

The piece of the X that undergoes inactivation probably contains the XIST gene and the other does not.

	One of the pieces of the X chromosome contains the SRY gene and the other one does not.
	The piece of the X chromosome that undergoes inactivation likely contains the pseudoautosomal region and the other piece does not.
	The piece of the X that undergoes inactivation probably contains the XIST gene and the other does not.
	When one piece of the X chromosome doesn\'t inactivate, it is because it can\'t pair with the Y chromosome and this causes the inactivation system not to work.
	None of the other statements are reasonable explanations about the mechanism of X-inactivation

The X-inactivation mechanism must require or recognize a specific locus or region on the X Chromosome ad must inactivate the Chromatin attached to this centre. When the X-chromosome breaks the fragment containing the X inactivation centre or locus becomes inactivated. The other fragment escapes inactivation as it is no longer attached.

It contains the XIST gene, whicg gets transcribed. The inactive X chromosome is costed by the Xist RNA.

Problem 48) Occasionally, a mouse X chromosome is broken into two pieces and each piece becomes attached to a different autosomal chromosome. In this event, the

Problem 48 Occasionally a mouse X chromosome is broken into

Solution

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