If in addition to the constraints on glucose concentration l

If, in addition to the constraints on glucose concentration listed previously, we have in the liver cell ATP concentration = 3 mM and ADP concentration = 1 mM, what is the theoretical concentration of glucose-6-phosphate at equilibrium at pH=7.4 and 37 C?

Express your answer to three significant figures and include the appropriate units.

Solution

Glucose + ATP->Glucose-6-Phosphate + ADP -16.5 KJ/mol

Keq is the ration of the products/reactants for a given reaction at equilibrium at a certain temperature.

K eq = [Products] / [Reactants]

-16500 J/mol = (-8.314 J/ mol^-1K^-1x 310 K) ln Keq

6.4019 = ln Keq Keq= e^6.4019= 603.019 =

[G6P][ADP]/ [ATP][Glucose] = [G6P](0.001)/(0.003 x 0.005)[G6P]

= (603.019 x 0.003 x 0.005)/0.001= 9.045 M