Describe feedback inhibition Describe feedback inhibitionSol

Solution

Feedback inhibition or the negative feedback loop is a homeostatic regulatory mechanism.

If the release of a hormone inhibits the further release of the same, then it is called as “negative feedback regulation or negative feedback loop.”

In some reactions, if the product is formed in excessive amounts, it binds to the rate limiting enzyme and inhibit the enzyme activity. This self regulation of the regulatory enzyme is an example of negative feedback regulation.

For example, high plasma concentrations of calcium stimulate the calcitonin release. Calcitonin decreases the blood calcium levels, so that the stimulus triggering its release also suppress. This is a negative feedback regulation. The calcitonin has opposite effects to that of PTH.