The sequence below is found in a betapleated sheet located o

The sequence below is found in a beta-pleated sheet located on the periphery of a domain. What is the most likely amino acid identity of position X?

IDVQFXLRVK

Solution

The given sequence is \"IDVQFXLRVK\". Given that, this sequence is found in beta-pleated sheet located in periphery of a domain.

In the peripheral region, proteins found are hydrophilic. So, \'X\' should be a hydrophilic amino acid.

The given sequence has a charge of +1. To make it neutral (charge =0); neutral domain will be more stable; the amino acid \'X\' should have -1 charge. So, the amino acid \'X\' can be Aspartic acid or Glutamic acid.

Glutamic acid is the most probable amino acid; it will fit into the domain created by phenylalanine present in the side of \'X\'.

One more thing to note is that hydrophilic amino acids in the periphery of domain are important for many cellular interactions which include signaling.