Will telomerase activity in normal mammalian cells prevent c

Will telomerase activity in normal mammalian cells prevent cellular aging and allow for the infinite division of cells without cellular senescence and death?

What experimental design would be best to test this?

Solution

As per recent studies answer should be yes.

Telomerase is is also called terminal transferase and it is a ribonucleoprotein which adds telomerea repeat sequences to 3\' end of chromosomes.they are involved in several biological functions they protect chromosomes from deletion ,recombination and the damages.

telomerase is active in normal stem cells and also in the cancer cells but it is absent in most of the somatic cells.

The importance of telomerase life in its activity of replacing telomeres. If Stella Maris is absent when a cell divides continuously at some point the daughter cells after 5270 cell divisions which age limit become old and the cell division stops.

Recent studies on mammalian cells show that telomere shortening does not appear to be an important factor in the aging of the differentiated cells of brain.

Telomerase us also promote tumorigenesis reminding its potentiality as anti aging therapy. Have a go inhibiting the tailor marriage activity is not enough to destroy the tumors but the surgery chemotherapy should be combined along with it.

When dirty lumeris activity is checked in mice the animals which are lacking this enzyme is much faster than the normal ones and they suffer from age related conditions. Splendor telomerase activity is restored in them it was found that there neurones and brain cells started working again and also the reverse the effects of aging.

Many scientists hope that telomerase therapy can do many things like extending lifespan and extending healthy life also

Experiments conducted on mice can prove this theory.