How does the Rb proteins phosphorylation state affect the ce

Solution

Rb proteins (retinoblastoma proteins pRB) regulate the cell cycle in association with different transcription factors and chromatin-associated complexes. Rb proteins regulate the cell cycle in association with different transcription factors and chromatin-associated complexes.

Gradual phosphorylation of Rb proteins causes their functional inactivation, which is regulated by cyclin-dependent kinases. As the retinoblastoma (Rb) is a tumour suppressor gene, their inactivation increases the risk of cancer development.