What differentiates smoldering multiple myeloma SMM from mon

What differentiates smoldering multiple myeloma (SMM) from monoclonal gammopathy of undetermined significance (MGUS)? (select all correct responses)

a. >20% clonal plasma cells in bone marrow

b. >10 g/dL serum monoclonal protein

c. >10% clonal plasma cells in bone marrow

d. >3 g/dL serum monoclonal protein

Explanation appreciated. Thanks.

Solution

c. >10% clonal plasma cells in bone marrow.

d. >3 g/dL serum monoclonal protein.

smoldering multiple myeloma (SMM) , also called also called asymptomatic multiple myeloma is diagnosed in patients with serum moniclonal protiens  >3 g/dL and or >10% clonal plasma cells in bone marrow in absence of lytic leisons, anemia, hypercalcemia and renal insufficiency.