Certain base analogs such as 5bromouracil cause mutations by

Certain base analogs such as 5-bromouracil cause mutations by chemically altering nitrogenous bases in nonreplicating DNA. True or False?

Solution

FALSE, 5-bromouracil is incorporated in place of thymine during DNA replication and does not affect the H bonding. However, presence of bromine atom makes it to tautomerize frequently into the enol form. The enol form of 5-bromouracil base pairs with guanine, instead of adenine.