Why is R eingle base deleli mutation within Proteincoding ly

Why is R eingle base deleli mutation within Protein-coding ly to hamful asingle base-nsi a: top codon. Thi cau earty termination of the polypeptide chain and almost always results in a nonfunctional protein A single base pair chan Single base par deletions change the codon to one that specifies also may change the codon to one hat specifi a stop codon, but single bas deletions ago at all points after th utation. A ge base-pair change may not ino acid and if does, the singl ngo whithin a protel be tolerated. nge the O Singla has delations lead to changi the amino aridin the protein that causes changing of tunctionR nt ia protein A singla haSA-pair rhanga may not ewan nhanga tha aminn arid, and daes. it\'T possiela tha Ringle amina acid change wirin a erntain can ha tnierated Single

Solution

Correct option- Single base-pair deletions change the codon to one that specifies a stop codon. This causes early termination of the polypeptide and almost always results in a malfunctional protein. A single-base pair change also may change the codon to one that specifies a stop codon, but it happens more rarely.

Explanation- Deletion of a base changes the whole open reading frame of a gene. So, the product of the gene changes. Due to deletion, often a codon changes into a stop codon. This is the cause of early termination during translation. So, the protein become malfunctional due to incomplete synthesis. This is lethal generally.

There is another type of mutation called base substitution. Due to single base pair substitution, a stop codon can be generated also. But the possibility is very low. In this case, only a single amino acid is changed probably in the sequence. A single amino acid change in a protein is very less effective generally.

Stopping translation due to stop codon formation is more harmful than synthesizing different amino acid chain. But sometimes after synthesizing some different amino acid the original sequence come back due to degeneracy.