The single best predictor of antipsychotic efficacy in a dru

The single best predictor of antipsychotic efficacy in a drug is an affinity for _____ receptors

A.  serotonin-2 (5-HT2).

B. serotonin-1 (5-HT1).
C. dopamine-2 (D2).
D. dopamine-1 (D1).

Solution

ANS: C. Dopamine-2 (D2).

Explanation:

Mechanisms of antipsychotics:

Antipsychotics can block dopamine receptors right away, but the full effect of the treatment of drug takes 2 weeks.

All antipsychotics binds to the D2 receptors, and some are also binds with other receptors. The D2 receptors can have higher affinity to bind so more positive results are taken placed and the disease symptoms are highly reduced.

Binding to D1 has no effect and it also can intensity promotes hyperactive symptoms.