If you are a pharmacist and your company is developing a sma

If you are a pharmacist and your company is developing a small molecule to regulate certain signal transduction pathway for the treatment of a specific disease, describe what approaches you can take?

Solution

Answer:

The drug molecule should specifically bind to the \"membrane bound receptor proteins\" so that it can alter the phosphorylation events to trigger changes in the signal transduction pathway. Therefore, the structure activity relationship of drug molecule should be carefully modified accordingly to bind to these receptors finally to trigger secondary messenger changes so that the diseases causing \"protein cascades\" can be inhibited.

Receptor docking and structure activity relationship of the drug molecules must be amended according intracellular & extracellular environment finally formulation of drug molecules must done to release the active ingredients inside the cellular environment to block signal transduction pathway.

For example, drug molecules that regulate the signal transduction pathways in treating \"cancer disease\" can act on \"Ras proteins through signal transduction\" via \"tyrosine kinase or protein kinase-1 membrane bound receptors so that it is possible to regulate certain signal transduction pathway for the treatment of a specific disease.

Formulation approaches, IC-50 therapeutic efficacy, biopharmaceutical &pharmacokinetic aspects and dosage regimen approaches are essentially examined to bind to the cell surface receptors

It is essential to study pharmacokinetics (biotransformation) of drug effect on the body followed by study of pharmacodynamics includes the study of drug absorption (A), distribution (D), metabolism (M), and excretion (E).