You block voltagegated Ca2 channels What happens to the acti

You block voltage-gated Ca2+ channels. What happens to the action potential?

Solution

Cardiac action potential and neuronal action potential are different in the initiation. The peak of cardiac action potential generated by calcium ion influx and by sodium ion in neurons. The calcium ion influx is through voltage gated ion channel. The another important role of voltage gated ion channel is to neurotransmitter release from the pre-synapse and this is responsible to generate the action potential at post-synapse. So if voltage gated channel is blocked the action potential will not be generated in both the cases. In cardiac system acetylcholine release will not happen and if previously present neurotransmitter depolarise the postsynaptic membrane the action potential peak will not be generate. Same in neurons the vesicles release will be hampered this cause either no action potential or number of action potential will be reduced. But if action potential is generated there will be no change in the quality of action potential.