Consider the above diagram of DNA molecules All molecules ar

Consider the above diagram of DNA molecules. All molecules are ~ 1000b long. Which molecule(s) could be a substrate for telomerase? C and D A, C and D B only A and D A only

Solution

Ans: A,C and D, Because telomere attaches to end of the chromosome at 3^\' end. Telomerase enzyme has the RNA template that attaches to the 3^\' end and starts the elongation process . In the next step it reverses and form a RNA- hair pin loop and elongates from the 5\' end.

In the case of B (DNA) , it is stable and hvaing telomeres at end that make them inert.