1 What are methylated CpGs How are they maintained on newly

1) What are methylated CpGs? How are they maintained on newly synthesized DNA strands? What type of epigenetic modification is CpG methylation?

2) What is genomic imprinting?

Solution

Genomic imprinting : Genomic imprinting refers to differential modification of maternal and paternal genetic contributions to zygote - resulting in differential expression of parental alleles duringdevelopment and/or in adult. One type of modification is addition of methyl groups to certain genes at CpG dinucleotides rendering these genes transcriptionally inactive.Hence Genomic imprinting turns off only specific genes.