How the protein avoids Levinthal paradox during foldingSolut

How the protein avoids Levinthal paradox during folding?

Solution

Answer:

Levinthal\'s paradox tells us that the amount of conformations available to a peptide is too large for it to sample randomly in order to achieve their native state, yet proteins in nature reach native states in a matter of seconds.

How do proteins fold in such time frame!

Local interactions initially lead to hydrophobic collapse which dramatically reduces conformational space the proteins need to explore. Proteins progressively lower free energy and then find native conformation.