One major function of liver cells hepatocytes is to detoxify

One major function of liver cells (hepatocytes) is to detoxify alcohol Based on this function what organelle (s) do you predict hepatocytes would contain large numbers of? Why? Certain cells within the pancreas function in the synthesis and secretion of the hormone insulin which is a protein Based on this function what organelle(s) do you predict these cells would contain large numbers of? Why? Your patient enters the emergency department with considerable blood loss from a blunt force trauma. You need to increase her bodily fluids to maintain blood pressure and systemic perfusion. You quickly administer an intravenous solution of NaCl. To avoid causing more harm, the tonicity of the I.V. solution should be

Solution

Hepatocytes are the main cells of liver parenchymal tissue and form about 70-85% of the liver\'s mass. These cells are involved in Protein synthesis, Protein storage, Transformation of carbohydrates, Synthesis of cholesterol, bile salts and phospholipids,Detoxification, modification, and excretion of exogenous and endogenous substances.

These cells contain abundat number of smooth endoplasmic reticulum. It is the type of ER which lacks ribosomes and functions in lipid manufacture and metabolism, the production of steroid hormones, and detoxification.

Hepatocytes have the ability to metabolize, detoxify, and inactivate exogenous compounds such as drugs, (drug metabolism), and insecticides, and endogenous compounds such as steroids. One of the detoxifying functions of hepatocytes is to modify ammonia into urea for excretion.