Could you please describe A protein And how it relates to al

Could you please describe A protein? And how it relates to alzhiemers?

Solution

Alzheimer’s is a chronic neurodegenerative disorder that causes dementia, first discovered in 1906 by Dr. Alois Alzheimer. About 60% to 70% of dementia cases are because of Alzheimer’s and the other symptoms include behavioral changes, loss of intellectual ability, problems with language and loss of self motivation. The gradual decline in bodily functions may cause death after three to nine years of diagnosis.

The etiology of Alzheimer’s is not clearly known but believing that about 70% of cases underlies genetic background involving a group of genes. Inheritance of autosomal dominant genes that causes Alzheimer’s (accounts for 0.1% people) trigger mutations in genes encoding APP (amyloid precursor protein), presenilin -1 and presenilin -2. These mutations cause accumulation of beta amyloid plaques, which are toxic to nerve.

The drugs used in the treatment of Alzheimer\'s disease include, Aricept (donepezil, acetylcholinesterase inhibitor), Razadyne (galantamine, acetylcholinesterase inhibitor) and Exelon (Rivastigmine, acetylcholinesterase inhibitor).