Immunology 1What is association of infectious Mono with hete

Immunology:

1.What is association of infectious Mono with heterophile antibodies?

2.How are heterophile antibodies detected in patient serum?

3.Is an elevated WBC common in infectious mono? (see resource links)

4.What type of antibody will infectious mono patients likely have in their serum lifelong?

5.Define heterophile antibody.

6.Describe role of RBCs from various species (sheep, beef, ox, horse) in differentiating various classes of heterophile antibodies.

7.Which antibody is more specific for infectious mono: (heterophile ab or EBV ab) and explain why it is thought to be so.

8.What are some minor complications which may occur if condition is misdiagnosed or goes undiagnosed not treated properly? (see links)

9.What are some major complications which may occur if condition is misdiagnosed or goes undiagnosed not treated properly? (see links)

10. How does the treatment differ for strep vs mono?

11.If monotest is negative and Dr. still suspects infectious mono, what test

   will Dr. most likely order?

12.In adults with infectious mono, how likely is it to test positive for mono

   i.e. what is monotest sensitivity?

13.Tammy has more lymphs than segs in her diff. Is this diff distribution

    normal for an adult?

14.What types of infection cause an increase in lymphs above the normal
  range?

Resources links:

Infectious Mono

http://labtestsonline.org/understanding/analytes/mono/tab/test

http://www.healthline.com/health/mononucleosis

Solution

1. Infectious mononucleosis is a disease caused by epstein barr virus. here we detect heterophile antibody against the virus. this test is positive after 4-6 weeks of onset of symptoms.

2. the antibody react with protein at specific lines so is called heterophile. 20% horse red cell suspension is used in this test which is agglutinated in presence of heterophile antibodies in patient serum.

3. in infectious mono there is increase in a specific type of WBC WHICH is a type of atypical lymphocyte. the lymphocyte seen are usually enlarged.

4.in this infection DOWNEY CELLS are seen. in lifelong consequence of this infection it cause many B LYMPHOCYTE ell to become plasma cell that secretecantibody against the virus.